--- a/build/toolchain/toolchain.gni
+++ b/build/toolchain/toolchain.gni
@@ -51,6 +51,10 @@
   }
 }
 
+declare_args() {
+  is_musl = false
+}
+
 # Extension for shared library files (including leading dot).
 if (is_apple) {
   shlib_extension = ".dylib"
--- a/build/config/rust.gni
+++ b/build/config/rust.gni
@@ -186,11 +186,23 @@
 rust_abi_target = ""
 if (is_linux || is_chromeos) {
   if (current_cpu == "arm64") {
-    rust_abi_target = "aarch64-unknown-linux-gnu"
+    if (is_musl) {
+      rust_abi_target = "aarch64-unknown-linux-musl"
+    } else {
+      rust_abi_target = "aarch64-unknown-linux-gnu"
+    }
   } else if (current_cpu == "x86") {
-    rust_abi_target = "i686-unknown-linux-gnu"
+    if (is_musl) {
+      rust_abi_target = "i686-unknown-linux-musl"
+    } else {
+      rust_abi_target = "i686-unknown-linux-gnu"
+    }
   } else if (current_cpu == "x64") {
-    rust_abi_target = "x86_64-unknown-linux-gnu"
+    if (is_musl) {
+      rust_abi_target = "x86_64-unknown-linux-musl"
+    } else {
+      rust_abi_target = "x86_64-unknown-linux-gnu"
+    }
   } else if (current_cpu == "arm") {
     if (arm_float_abi == "hard") {
       float_suffix = "hf"
@@ -199,13 +211,25 @@
     }
     if (arm_arch == "armv7-a" || arm_arch == "armv7") {
       # No way to inform Rust about the -a suffix.
-      rust_abi_target = "armv7-unknown-linux-gnueabi" + float_suffix
+      if (is_musl) {
+        rust_abi_target = "armv7-unknown-linux-musleabi" + float_suffix
+      } else {
+        rust_abi_target = "armv7-unknown-linux-gnueabi" + float_suffix
+      }
     } else {
-      rust_abi_target = "arm-unknown-linux-gnueabi" + float_suffix
+      if (is_musl) {
+        rust_abi_target = "arm-unknown-linux-musleabi" + float_suffix
+      } else {
+        rust_abi_target = "arm-unknown-linux-gnueabi" + float_suffix
+      }
     }
   } else {
     # Best guess for other future platforms.
-    rust_abi_target = current_cpu + "-unknown-linux-gnu"
+    if (is_musl) {
+      rust_abi_target = current_cpu + "-unknown-linux-musl"
+    } else {
+      rust_abi_target = current_cpu + "-unknown-linux-gnu"
+    }
   }
 } else if (is_android) {
   import("//build/config/android/abi.gni")